- First academic journal in Canada: see Queen's Quarterly
- First Asian student: see Toshi Ikehara
- First building on main campus: see Summerhill
- First Canadian president of the International Federation of University Women: see Allie Vibert Douglas
- First Chair in Canadian History in Canada: see the Douglas Chair
- First chancellor: see The Rev. John Cook
- First Dean of Women: see Caroline McNeill
- First electricity installation in Kingston: see William Lawton Goodwin
- First female AMS president: Dorothy Wardle
- Fist female ambassador for Canada: Elizabeth MacCallum
- First female chancellor: see Agnes McCausland Benidickson
- First female department head: Hilda Laird, see Department of German
- First female editor of the Journal: see Charlotte Whitton
- First female faculty member: see Wilhelmina Gordon
- First female graduates (also first in Ontario): see Women at Queen's, Admission of
- First female honorary degree recipient: see Lady Aberdeen
- First female honorary degree recipient (also first in Canada): see Honorary Degrees
- First female student: see Elizabeth de St Remy
- First hockey game at Queen's: see Hockey, First Game of
- First home for Queen's: see Colborne Street
- First honorary degree recipients: see Honorary Degrees
- First Nobel Prize laureate: see Art McDonald
- First principal: see The Rev. Thomas Liddell
- First professor: see The Rev. Peter Colin Campbell
- First professor of anatomy in Canada: see Frederick Etherington
- First rector: The Rev. S. Dyde, see Rector
- First sport: see Athletics
- First student: see The Rev. George Bell
- First student and graduate of colour: see Robert Sutherland
- First student organization: see Dialectic Society
- First telephone on campus: see Alexander Melville Bell