Completed in 1966 and located on Division Street, Dupuis Hall is named after Nathan Fellowes Dupuis, an influential professor of mathematics at Queen's in the late 19th and early 20th centuries, and a founder of the engineering and applied science faculty.
The concrete of the exterior is broken up by small sections of decorative limestone facing in an attempt to appease the more traditionally-minded people on campus who objected to a building being erected at Queen's without the usual limestone.