This is an endothelial cell, the cell type that lines your blood vessels. This cell is neat because we grew it from a routine blood sample of a person with a common bleeding disorder, von Willebrand disease (VWD), and used it to figure out how their genetic mutation lead to a deficiency of von Willebrand factor (VWF), a vital clotting protein. VWF (green) is supposed to be stored in rod-shaped packets, but we found that proper storage was eliminated in this cell. Likely, the VWF is trapped, and cannot escape the cell to help with clotting.
Submission Year:
2015-16
Photographer's affiliation:
Graduate student
Academic areas:
Graduate Studies and Postdoctoral Affairs
Health Sciences
Photo:
Categories:
Grad student
School of Graduate Studies
Faculty of Health Sciences
School of Medicine
Department of Pathology and Molecular Medicine
Fundamental Principles of Nature: from Discovery to Application and Innovation
Health, Wellness and the Determinants of Human Health
Location of photograph:
Molecular Hemostasis Laboratory, 成人大片 University
Photographer's name:
Lara Casey
Display Photographers Affiltion + Faculty or Department:
Graduate Student, Pathology and Molecular Medicine