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    Chemical bonds

    Chemical bonds

    Whether she鈥檚 working in the classroom or on the other side of the world, Dr. Cathy Crudden鈥檚 chemistry creates all sorts of connections.

    I鈥檓 a bit early for my meeting with Dr. Cathy Crudden, so when I arrive at her office she鈥檚 in the middle of discussing a current research project with one of her students. Crudden invites me in anyway and it鈥檚 immediately obvious that working with students is a huge job perk for her.

    鈥淪tudents are incredibly fun to work with. Everyone has a different approach and we encourage them to have their own ideas and because of that, they bring so much to the science,鈥 says Crudden, a professor in the Department of Chemistry.

    The science, in this case, revolves around questions of catalysis 鈥 acceleration of chemical reactions 鈥 and chirality 鈥 structural asymmetries and 鈥渕irror images鈥 in different forms of the same molecule. Crudden and her group are involved in developing new reactions to prepare compounds of interest to the pharmaceutical, environment and energy industries.

    Of particular note is their recent work published in Nature Chemistry, where the Crudden group described a process to allow organic compounds to bind to metal surfaces. They have prepared the most stable self-assembled-monolayers on gold reported since the original report of organic-on-metal coatings in 1983. These results are considered game-changing. At only 1/100,000th the width of a human hair, these films have already been shown to reduce corrosion and dramatically improve stability and reproducibility in biosensors. Their potential for wide application is unquestionable.

    And discoveries like this rely on the close collaboration with her students. For the last few months, the Crudden group had close to 20 undergraduate students, graduate students and post-doctoral fellows on the team, which made for a busy summer.

    鈥淥ur lab is very different from your cookie-cutter, undergraduate lab where the experiments are designed to work,鈥 says Crudden. 鈥淚n my lab, students get to do things that won鈥檛 necessarily work. While that doesn鈥檛 sound great, it鈥檚 another important approach to exploring chemistry, which at times can be unpredictable. It鈥檚 a very challenging, but very fun experience.鈥

    Perseverance is critical in research. You鈥檝e got to be stubborn. That said, a successful experiment is so rewarding. That鈥檚 what makes it all worthwhile.鈥

    Furthermore, opportunities for working in Crudden鈥檚 lab aren鈥檛 limited to Kingston, or even Canada, thanks to her longstanding connection with Nagoya University in central Japan.

    With no less than four trips to Nagoya per year, a huge part of Crudden鈥檚 career is based across the globe where she studied for part of her PhD and returned to for her sabbatical year.

    In 2013, Crudden became involved with the creation and development of the Institute of Transformative Bio-Molecules (ITbM) 鈥 a research facility based at Nagoya dedicated to solving scientific problems and making these solutions readily available for researchers all over the world. Projects at the ITbM currently include the development of molecules that control biotic function and production, as well as developing innovative bio-imaging technologies.

    鈥淛apan is an incredible country and working with researchers over there brings a totally different perspective and intensity to the table,鈥 says Crudden, who now holds an adjunct faculty position at Nagoya. 鈥淕oing to Japan as a student was such a great experience for me and it really is a huge pleasure to be able to send students there.鈥

    Trainees in Crudden鈥檚 lab are encouraged to take research positions at Nagoya, just as students at Nagoya are encouraged to come to Queen鈥檚. In ITbM鈥檚 first year of operations, Crudden sent three Queen鈥檚 students to the Institute. Two undergraduate Queen鈥檚 students conducted research there this past summer. 鈥淗aving Canadian and Japanese students able to interact and learn from each other is a huge benefit of having this connection with Nagoya,鈥 says Crudden.

    With only about 14 per cent of researchers in Japan being female, the relationship that Crudden has cultivated with Nagoya has also been encouraging for budding female scientists at the university.

    鈥淛apan is very keen to increase their number of female scientists and many scientists over there will often talk to me about how I, as a female scientist, balance my work and home life,鈥 Crudden says, adding that she鈥檚 seeing many more female students and researchers at universities than she did when she was in Japan as a graduate student.

    As a leader in her research field, Crudden is a role model for women in science and as an acclaimed mentor, clearly has the ability to inspire passion in her students. However, this goes both ways. At the close of our interview, I notice a number of empty champagne bottles that line the window sill of her office. I ask her what these mementos represent and she responds that each bottle celebrates the success of one of her students.

    鈥淲hen one of my graduate students finishes or a post-doctoral fellow secures a job, we celebrate as a group by cracking open a bottle of bubbly,鈥 Crudden tells me, adding that the bottles are all signed and dated by each student 鈥 a reminder of their work and success under her guidance.